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KPV is a short three-amino-acid peptide derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH).
Despite its small size, KPV has attracted research interest for its anti-inflammatory activity, particularly in studies involving intestinal inflammation, skin cells, and immune signaling.
Product Information
KPV consists of the amino acids lysine-proline-valine and represents the C-terminal tripeptide of α-MSH.
Research suggests that KPV can retain important anti-inflammatory properties associated with α-MSH while avoiding many of the broader melanocortin effects of the complete peptide.
How Does KPV Work?
KPV appears to influence inflammatory signaling and melanocortin-related pathways. Its precise receptor mechanism is still being investigated.
KPV Benefits
Supports Anti-Inflammatory Research:
KPV has demonstrated anti-inflammatory activity in experimental models. Research has examined reductions in inflammatory signaling and immune-cell activity following exposure to the peptide.
Research Into Intestinal Inflammation:
Animal studies have investigated KPV in models of inflammatory bowel disease and colitis. Results have included reductions in inflammatory markers and improvements in intestinal inflammatory responses.
Supports Skin and Cellular Research:
Studies using human keratinocytes have shown that KPV can influence inflammatory signaling within skin cells. This has made it an interesting candidate for research into peptide-based modulation of skin inflammation.
KPV Side Effects
Human safety data remain limited because most KPV research is preclinical. Findings from cell and animal models cannot establish a complete human side-effect profile.
KPV Dosage
There is no standardized human clinical dose established for KPV. Published studies use experimental concentrations and animal-specific dosing protocols, which should not be directly converted into human dosing.
Research References
Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo. Pharmacology & Therapeutics. 2008. PMID: 18612139.
PubMed
Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Peptides. PMID: 18092346.
PubMed
Maaser C, Kannengiesser K, Specht C, et al. α-MSH, MSH 11-13 KPV and ACTH signalling in human keratinocyte cells. Journal of Investigative Dermatology. 2004. PMID: 15102092.
PubMed
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The information provided in these pages is intended for educational and informational purposes only and should not be considered medical advice, diagnosis, or a recommendation to use any peptide. Research doses are included to describe published study protocols and are not individualized dosing instructions. Product quality, formulation, purity, route of administration, regulatory status, and availability may vary between suppliers and jurisdictions.
